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KMID : 0357920030370060432
Korean Journal of Pathology
2003 Volume.37 No. 6 p.432 ~ p.434
Primary Diffuse Large Q-cell Lymphoma of the Prostate
Kim Dong-Chul

Lee Ah-Won
Kang Chang-Suk
Park Gyeong-Sin
Han Kyung-Ja
Abstract
Primary lymphomas of the prostate are extremely rare and can mimic other more common prostatic lesions clinically. We report a case of primary diffuse large B-cell lymphoma of the prostate in an 81-year-old man. The patient presented with voiding difficulty as an initial symptom and enlargement of the prostate on rectal digital examination. Transurethral prostatic resestion was performed. On microscopic examintion, atypicaly lymphoid cells infittrated and replaced the prostatic parenchyma. The tumor cells had large nuclei with irregular nuclear membrane and vesicular clumped chromatin. Nucleoli were not distinct and the cells had scanty cytoplasm. Immunohistochemically, the tumor cells were immunoreactive for CD20 and CD79a but not reactive for CD5, BCL-2 and BCL-6. Histopathological diagnosis was diffuse large B-cell lymphoma of the prostate. The patient received 5 cycles of chemotherapy after histologic diagnosis but died from pulmonary and scrotal metastases 6 months later.
KEYWORD
Prostate-Lymphoma, Large Cell, Diffuse
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